Fluorescence molecular imaging (FMI) is becoming a powerful tool to improve surgical precision and diagnostics. Although significant advances have been made in imaging technology and contrast agents, ...

A fundamental challenge in fluorescence microscopy is the photon shot noise arising from the inevitable stochasticity of photon detection. Noise increases measurement uncertainty and limits imaging ...

Limits of patch-based training However, most existing studies follow practices from natural-image processing by randomly cropping large images into small patches, typically 128×128 pixels, for data ...

Peking University, June 9, 2026: Recent years have witnessed great advances in applying deep learning to improve fluorescence microscopy imaging. However, enhancing the fidelity of image restoration ...