Lymph nodes are key control centers in the immune system and play an important role in defending the body against infections ...

A new study maps the organisation of immune and stromal cells in lymph nodes and shows how loss of this organisation affects ...

Architectural principles of lymphoma-induced lymph node tissue remodeling” F. Czernilofzky, A. Mathoiudaki, L. Jopp-Saile, R. Lutz, D. Vonficht, X. Wang, C. Schiederjohann, H. Voehringer, T. Roider, M ...

Tumors, such as melanoma, release nanovesicles called exosomes (gray) that travel and lodge in the lymph nodes. There they corrupt the behavior of lymph cells. The lymphatic vessels (green) branch out ...

This illustration depicts a newly identified pathway, an intranodal lympho-venous shunt, within a lymph node that enables lymph fluid to flow directly into a blood vessel. Typically, lymph nodes serve ...

In almost all solid tumors—i.e. cancers with a solid tissue structure—the detection of tumor cells in the lymph nodes is considered a decisive marker for the progression of the disease. Lymph node ...

Penn Engineers have redesigned a key component of lipid nanoparticles (LNPs), the delivery vehicles behind mRNA vaccines, to ...

A new nanoparticle design directs mRNA vaccines to lymph nodes. The strategy reduced off-target delivery, maintained immune ...