Lymphocyte development relies on the deliberate induction and precise repair of DNA double-strand breaks (DSBs) to generate the diverse repertoire of antigen receptors that underpin adaptive immunity.

During B and T lymphocyte development, antigen receptor diversity arises through V(D)J recombination, a process driven by the RAG1/2 endonuclease that introduces programmed double-stranded DNA breaks ...

Atypical lymphocytes are types of white blood cells that a person’s immune system produces. They help fight infections and diseases. High levels of atypical lymphocytes may indicate health issues.

Intraepithelial lymphocytosis is a complex immunological phenomenon. It commonly affects the gastrointestinal tract, where damage to the lining of tissue causes the number of lymphocytes (a type of ...

Effect of BL-8040, high-affinity CXCR4 antagonist, on T-cell infiltration, tumor growth, and synergy with immunomodulatory agents. This is an ASCO Meeting Abstract from the 2017 ASCO Annual Meeting I.