In prokaryotes, DNA replication initiates at a single defined origin and proceeds bidirectionally via a multiprotein replisome that unwinds the duplex and synthesises new strands. Elongation is ...

Brandt Eichman and Walter Chazin, professors of biochemistry, have worked together to provide a better understanding of how exactly DNA replication is initiated in eukaryotes. Using Vanderbilt's state ...

Thymine metabolism in prokaryotes encompasses both de novo synthesis of deoxythymidine triphosphate (dTTP) via the reductive branch of pyrimidine biosynthesis and salvage pathways that recover ...

Prokaryotic single-celled organisms, the ancestors of modern-day bacteria and archaea, are the most ancient form of life on our planet, first appearing roughly 3.5 billion years ago. The first ...