Nature

Structure-based identification of compounds with potential as selective BLT1 antagonists

The pro-inflammatory molecule leukotriene B4 binds to the leukotriene B4 receptors 1 and 2 (BLT1 and BLT2). Although BLT1 has potential as a target for treating inflammatory diseases, no selective ...
Nature

Structure-based discovery of a new type of scaffold compound as binding competitors for protein-bound Uremic Toxins

Protein-bound uremic toxins (PBUTs) are the main cause of uremia, but traditional hemodialysis is ineffective in removing them because of their strong ability to bind to human serum albumin (HSA), ...
Science Daily

Exploring the structures of xenon-containing crystallites

Noble gases have a reputation for being unreactive, inert elements, but more than 60 years ago Neil Bartlett demonstrated the first way to bond xenon. He created XePtF6, an orange-yellow solid.
The Conversation

Only 1% of chemical compounds have been discovered – here’s how we search for others that could change the world

The universe is flooded with billions of chemicals, each a tiny pinprick of potential. And we’ve only identified 1% of them. Scientists believe undiscovered chemical compounds could help remove ...
Phys.org

For the first time, scientists have access to a comprehensive data set for identifying unknown compounds

Scientists from the laboratory of Dr. Tomáš Pluskal at IOCB Prague are helping colleagues around the world identify previously unknown compounds. They have created an extensive library called MS n Lib ...
Frontiers

Mechanisms of Action of Plant-Derived Compounds in Animal Nutrition and Their Role in Mitigating Livestock Environmental Emissions

Livestock agriculture faces mounting pressure to reduce its environmental footprint, particularly enteric methane, urinary ...