The Institute of Neurosciences (IN), a joint center of the Spanish National Research Council (CSIC) and the Miguel Hernández University (UMH) of Elche, leads, together with Keio University in Tokyo, a ...

In the brain, highly specific connections called synapses link nerve cells and transmit electrical signals in a targeted manner. Despite decades of research, how synapses form during brain development ...

Schematic representation of axonal transport vesicles (blue) carrying presynaptic proteins (SV and AZ proteins). Kinesin motor proteins (KIF1A) attach these vesicles and carry them along the axons to ...

Brain function relies on the generation of a large variety of morphologically and functionally diverse, but specific, neuronal synapses. Here we show that, in mice, the initial formation of synapses ...

A team of scientists from the University of Cologne's Institute of Biochemistry has made a decisive discovery about the molecular basis of synapse formation in the central nervous system. They studied ...

Our appreciation of the contributions of immune signalling to brain development and function is growing, but we still know little about the specific immune cell types and mediators involved. Barron et ...

Complex protein interactions at synapses are essential for memory formation in our brains, but the mechanisms behind these processes remain poorly understood. Now, researchers from Japan have ...

Representative cryo-electron microscopy image: a coloured image of the 3D structure of gephyrin, which was calculated from the data. A team of scientists from the University of Cologne’s Institute of ...

“You expect nerve cells to grow to find the one they like,” said Alan Roberts, a neuroscientist at the University of Bristol in the U.K. and lead author of the study. “These experiments suggest they ...

Scientists from Oregon Health & Science University (OHSU) and the University of Edinburgh have discovered that a little-understood junction that connects neurons to oligodendrocyte precursor cells ...

Co-written with Jai Liester. Silent synapses represent one of neuroscience's most fascinating discoveries—connections between neurons that lie dormant until activated by specific triggers. These ...

The formation of excitatory and inhibitory synapses between neurons during early development gives rise to the neuronal networks that enable sensory and cognitive functions in humans. Inhibitory ...