The EMBO Journal

SorLA restricts TNFα release from microglia to shape a glioma-supportive brain microenvironment

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. SorLA, encoded by the gene SORL1, is an ...
The EMBO Journal

The plant‐specific DDR factor SOG1 increases chromatin mobility in response to DNA damage

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. In plants, increased chromatin mobility ...
The EMBO Journal

Constructive correction

A fundamental tenet of the scientific process is that science is self‐correcting. Efficient correction of the scientific literature requires a more nuanced set of policies and tools that lower the bar ...
The EMBO Journal

The structure of fly Teneurin‐m reveals an asymmetric self‐assembly that allows expansion into zippers

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Teneurins are conserved cell adhesion ...
The EMBO Journal

MitoStores : a place for precursors to ride out the storm

This cover highlights the article DNA damage repair kinase DNA-PK and cGAS synergize to induce cancer-related inflammation in glioblastoma by Clara Taffoni, Johanna Marines, Nadine Laguette and ...
The EMBO Journal

Egr2 to the rescue: nanoparticles revitalize natural killer cells in the fight against cancer

Reversal of tumor-induced natural killer (NK) cell dysfunction remains a major hurdle to overcome for the clinical success of immunotherapies based on NK cells targeting solid tumors. New research in ...
The EMBO Journal

Rassf7a promotes spinal cord regeneration and controls spindle orientation in neural progenitor cells

This month's cover highlights the article Endothelial transmigration hotspots limit vascular leakage through heterogeneous expression of ICAM‐1 by Max Grönloh, Janine Arts, Jaap van Buul and ...
The EMBO Journal

Structural basis for conformational switching and GTP loading of the large G protein atlastin

Atlastin, a member of the dynamin superfamily, is known to catalyse homotypic membrane fusion in the smooth endoplasmic reticulum (ER). Recent studies of atlastin have elucidated key features about ...
The EMBO Journal

Stoichiometry of the T‐cell receptor–CD3 complex and key intermediates assembled in the endoplasmic reticulum

The T‐cell receptor (TCR)–CD3 complex is critical for T‐cell development and function, and represents one of the most complex transmembrane receptors. Models of different stoichiometry and valency ...
The EMBO Journal

Arginine dependency is a therapeutically exploitable vulnerability in chronic myeloid leukaemic stem cells

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. A complete lack of urea cycle function is a ...
The EMBO Journal

The signaling adapter p62 is an important mediator of T helper 2 cell function and allergic airway inflammation

Naïve T helper (Th) cells differentiate in response to antigen stimulation into either Th1 or Th2 effector cells, which are characterized by the secretion of different set of cytokines. Th2 ...
The EMBO Journal

Acidity suppresses CD8 + T-cell function by perturbing IL-2, mTORC1, and c-Myc signaling

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. CD8 + T cells have critical roles in tumor ...