Drugs are metabolized in the liver using several enzyme-catalyzed processes. These enzymes are collectively referred to as the hepatic microsomal enzyme system, and they are usually present in the ...
Enzyme inhibitors play a pivotal role in pharmaceutical and nutraceutical industries. The primary understanding of the action of inhibitors helps pharmacologists during the design process for ...
Recent evidence suggests that natural products are much more than simply agents of “microbial warfare” and actually play critical roles in bacterial pathogenesis and communication. In particular, ...
High-fat diet (HFD) feeding in mice promotes induction of aldose reductase (AR) activity, expression, and senescence of adipocytes in subcutaneous adipose tissue (scAT), according to a new study in ...
Epigenetic drug discovery and development programs have attracted much attention and investment in recent years. This is driven by the potential to develop novel therapeutic strategies that can ...
A new study reveals that several drugs for treating haematological cancers are less effective than expected in inhibiting a special enzyme. Researchers have also identified new lead compounds that ...
In the context of the coronavirus disease 2019 (COVID-19) pandemic, with over 3.5 million deaths and counting as of June 9, 2021, the development of effective antivirals remains essential. This ...
Chemotherapy drugs that target cancer cells without damaging normal cells remain one of the key goals of precision medicine ...
ALAMEDA, Calif. & CAMBRIDGE, England--(BUSINESS WIRE)--Exelixis, Inc. (Nasdaq: EXEL) and STORM Therapeutics (STORM) today announced that they have entered into an exclusive collaboration and license ...
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