The maintenance of genomic integrity in eukaryotic cells relies on the DNA damage checkpoint, a sophisticated signalling pathway that detects DNA lesions, transduces signals via sensor kinases and ...

Phase II Study of Adavosertib in Patients With Tumors Containing BRCA1 and BRCA2 Mutations: Results From the NCI-MATCH ECOG-ACRIN Cancer Research Group (EAY131) Subprotocol Z1I We integrated ...

Genome instability can cause numerous diseases. Cells have effective DNA repair mechanisms at their disposal. A research team has now gained new insights into the DNA damage response. Whenever cells ...

Researchers identified a new, sticky form of mitochondrial DNA damage that builds up at dramatically higher levels than in nuclear DNA. These lesions disrupt energy production and activate ...

A protein best known for driving cancer growth also helps damaged tumor cells survive by repairing their DNA, according to a new study that could influence how some cancers are treated. Researchers at ...

The Korea Research Institute of Standards and Science has developed an ultrasensitive immunoassay-based analytical platform that can detect and quantify trace amounts of "Small Excised Damaged DNA ...