The maintenance of genomic integrity in eukaryotic cells relies on the DNA damage checkpoint, a sophisticated signalling pathway that detects DNA lesions, transduces signals via sensor kinases and ...

Phase II Study of Adavosertib in Patients With Tumors Containing BRCA1 and BRCA2 Mutations: Results From the NCI-MATCH ECOG-ACRIN Cancer Research Group (EAY131) Subprotocol Z1I We integrated ...

In current health lore, antioxidants are well known to reduce the amount of “reactive oxygen species” -- cell-damaging molecules that are byproducts of cellular metabolism -- is critical to staying ...

Genome instability can cause numerous diseases. Cells have effective DNA repair mechanisms at their disposal. A research team has now gained new insights into the DNA damage response. Whenever cells ...

Researchers identified a new, sticky form of mitochondrial DNA damage that builds up at dramatically higher levels than in nuclear DNA. These lesions disrupt energy production and activate ...

While most known types of DNA damage are fixed by our cells' in-house DNA repair mechanisms, some forms of DNA damage evade repair and can persist for many years, new research shows. This means that ...

A protein best known for driving cancer growth also helps damaged tumor cells survive by repairing their DNA, according to a new study that could influence how some cancers are treated. Researchers at ...