Despite randomised clinical trials (RCTs) being the gold standard for drug approval studies, the shift towards precision medicine has increased the use of single-arm trials (SATs). SATs lack results ...

Introduce The ExtRA Capacity Test, a measure for assessing shoulder muscle performance. Assess its reliability, validity and present normative scores in a large sample of asymptomatic adults. The ...

The digital era offers opportunities to engage this age group in interventions in new and appealing ways. Objective: This systematic review evaluated the efficacy and external validity of electronic ...

Background: Asthma is a heterogeneous disease with a wide range of clinical phenotypes, not all of which may be encompassed in the subjects included in randomised controlled trials (RCTs). This makes ...

Objective To explore factors that potentially impact external validation performance while developing and validating a prognostic model for hospital admissions (HAs) in complex older general practice ...

Background: Mobile health (mHealth) interventions are effective in promoting physical activity (PA); however, the degree to which external validity indicators are reported is unclear. Objective: The ...

The following represents disclosure information provided by the author of this manuscript. All relationships are considered compensated unless otherwise noted. Relationships are self-held unless noted ...

Clinical trials are the foundation of medical innovation, enabling life sciences companies to evaluate the safety and efficacy of new treatments. However, traditional study designs face increasing ...

External solid-state drives (SSDs) have come a long way, delivering faster performance, improved durability, and more storage choices than ever. Whether you're a gamer chasing shorter load times, a ...

The use of RWD data in place of placebo groups is improving various elements across the clinical trial space. Clinical trials are possibly the most vital access of the drug development process, and ...